Imbalance of mitochondrial fusion and fission in ischemic heart disease

Author(s): Alexander V. Blagov , Mariam Bagheri Ekta, Irina I. Nadelyaeva, Mikhail A. Popov, Vasily N. Sukhorukov, Alexander N. Orekhov

Cardiovascular diseases are one of the leading causes of death in the world. One of the main diseases of this group is coronary heart disease, the treatment of which does not always have a positive effect. The development of new drugs requires finding new pathological targets that affect the development of the disease. Proteins that regulate mitochondrial dynamics, namely, mitochondrial division and mitochondrial fusion, can act as such targets, since a change in these processes has been noted for a number of cardiovascular diseases. In this review, we will consider the mechanism of changes in these processes in the context of the pathogenesis of ischemia, as well as note the current state of therapeutic developments in this area.