High Genetic Risk of Diabetes after a High-Carbohydrate Meal

Author(s): Rishabh B

The aim of our study was to evaluate postprandial metabolic changes in healthy men with a high genetic risk for diabetes, following two meals with high polynutrient content. Amount of change, the study was performed in 21 homozygous non-diabetic men carrying the high-risk genotype or locus rs7901695. During two challenges, subjects received standard 450 kcal isothermal liquid meals: HC contains many starchy substances, carbohydrates: 89% energy and normal carbohydrates NC, carbohydrates: 45% energy. Fasting and postprandial plasma samples were analyzed for metabolite profiles by non-targeted metabolites. Metabolic fingerprinting was performed on an ultra-high performance liquid chromatography system connected to an Funnel quadrupole time-of-flight mass spectrometer.