Development of new biomarkers and early prognosis for drugs causing hepatotoxicity through different metabolomic approaches

Author(s): Nalini Kanta Sahoo

Hepatotoxicity (from hepatictoxicity) implies chemical-driven liver damage. Drug-induced liver injury is a cause of acute and chronic liver disease.The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents, when taken in overdoses and sometimes even when introduced within therapeutic ranges, may injure the organ. Other chemical agents, such as those used in laboratories and industries, natural chemicals (e.g., microcystins) and herbal remedies can also induce hepatotoxicity. Chemicals that cause liver injury are called hepatotoxins.