Abstract

Development of Multifuncionalised Polymeric Nanoprobes for Diagnostic and Therapeutic Applications

Author(s): Rosario M Sanchez-Martin

Polymeric nanoparticles offer a great flexibility adapting its chemistry composition, size, stability, morphology and surface functionality. As a result, they are used in Biomedicine as drugs carrier systems and diagnostic agents for a wide range of applications in diagnosis, therapy and theranostics [1]. NanoChemBio lab is focused on the design, synthesis, scale-up and preclinical evaluation of multifuncionalised nanoprobes to be apply in biomedicine. Herein we will present our more recent findings. Currently we are carried on the validation of a theranostic nanodevice to treat breast cancer and to monitor treatment efficiency together with to determine localization of the tumour focus [2,3]. In another hand, we are developing a robust and stable targeting nanoprobe that allows for active targeting of either a fluorophore for active tracking or a drug for monitoring specific cell responses depending on the expression levels of surface proteins [4]. Related to our latest diagnostic advances, we have implemented a nanotechnology-based approach for capturing and detecting nucleic acids by flow cytometry will be presented [5]. This system allows for the detection of biotinylated molecular products followed by simple detection using a standard flow cytometer, a widely used platform in clinical and molecular laboratories, and therefore, is easy to implement.