Commentary on Pyrrole-Imidazole Alkaloids.

Author(s): Mohamad Taleuzzaman

Synthesize marine sponge-deriving pyrrole-imidazole alkaloids. This now nearly triple- digit membered community has been growing exponentially in the last 20 years, both in terms of new representatives and topological complexity − from simple, achiral oroidine to the breathtaking 12-ring stylissadines A and B, each possessing 16 stereocenters. This review will account for the progress in achieving the total synthesis of the more biologically enticing members of this class of natural products