Commentary on Pyridine Compounds & its Antimicrobial Activities

Author(s): Maria Marinescu

Pyridine is a privileged nucleus among heterocycles; its compounds have been noted
for their therapeutic properties, such as antimicrobial, antiviral, antitumor, analgesic,
anticonvulsant, anti-inflammatory, antioxidant, anti-Alzheimer’s, anti-ulcer or antidiabetic.
It is known that a pyridine compound, which also contains a heterocycle, has improved
therapeutic properties. The singular presence of the pyridine nucleus, or its one together
with one or more heterocycles, as well as a simple hydrocarbon linker, or grafted with
organic groups, gives the key molecule a certain geometry, which determines an
interaction with a specific protein, and defines the antimicrobial and antiviral selectivity
for the target molecule. Moreover, an important role of pyridine in medicinal chemistry is
to improve water solubility due to its poor basicity.