Cardiac Development in Zebra Fish through the Retinoic Acid Signaling Pathway

Author(s): Delgado M J

Adipose acid- binding protein 3(FABP3) is a member of the intracellular lipid- binding protein family, and is primarily expressed in cardiac muscle towel. Preliminarily, we set up that FABP3 is largely expressed in cases with ventricular- septal blights and is frequently used as a tube biomarker in idiopathic ballooned cardiomyopathy, and may play a significant part in the development of these blights in humans. In the present study, we aimed to probe the part of FABP3 in the embryonic development of the zebra fish heart, and specifically how morphine (MO) intermediated knockdown of FABP3 would affect heart development in this species. Our results revealed that knockdown of FABP3 caused significant impairment of cardiac development observed, including experimental detention, pericardial edema, a direct heart tube phenotype, deficient cardiac circle conformation, abnormal positioning.