Attenuates Oxidative Stress and Cardiac Dysrhythmia in Isoproterenol-Induced Cardiomyopathy in Rats

Author(s): Prashant Sharma

Citrus medical for 15 days on with ISO( 85 mg/ kg,s.c.) on the 14th and 15th day. ISO convinced cardiac dysfunction, increased lipid perox. Generally known as Otroj, is an important medicinal factory reputed for its nutritional and remedial uses. The present work was accepted to probe the defensive effect of the ethanol excerpt of opt raj (EEOT) against isoproterenol (ISO)- convinced cardio toxin in rats. In addition, the antioxidant exertion and the phenolic and flavonoid contents were determined. Rats were administered EETO (250 and 500 mg/ kg) or vehicle orally iodation and revision of myocyte- injury specific marker enzymes. ISO also showed an increase in situations of tube cholesterol, triglycerides (TG), LDL- C, and VLDL-C. Also, the histological examinations showed myocardial necrosis and inflammation. EETO treatment brought the below parameters towards normal position. Also, in vitro DPPH radical scavenging and β- carotene- linoleic acid tests of the EEOT antioxidant exertion in both assays used.