Adult Patients from One Nephrology Center with Renal Amyloidosis: Epidemiological, Clinical, and Laboratory Profile

Author(s): Neeraj Dhaun*

One of the primary differential diagnosis for nephrotic proteinuria in adults and the elderly is renal amyloidosis. This study with the most significant series in our nation aims to add to the clinical, etiological, and epidemiological research on renal amyloidosis. In a retrospective analysis conducted between 1975 and 2019, 310 cases of renal amyloidosis with histologically verified and typed were chosen for this investigation. The average age was 53.8 15.4 years, with 209 men and 101 women in attendance (range, 17–84 years). Of the 310 cases, renal amyloidosis AA was found in 255 (82.3%) and non-AA amyloidosis in 55 (17.7%). AA amyloidosis was primarily brought on by infections, with tuberculosis being the most common aetiology. An average of 177 months passed between the development of the underlying condition and the diagnosis of renal amyloidosis. At the time of diagnosis, nephrotic syndrome (84%), chronic renal failure (30.3%), and end-stage renal disease (37.8%) were the most prevalent symptoms. Mortality occurred in 60 cases after a mean follow-up of 16 months (range, 0-68 months). Given the high prevalence of AA amyloidosis in our nation, preventing the occurrence of this dangerous disease requires increased awareness of the right management of infectious and chronic inflammatory diseases.