Abstract

Admission hyperglycemia and the no-reflow phenomenon in patients with acute myocardial infarction

Author(s): Omar F Tawfik, Mosbah T Hassanin, Mohy Eldin Aboelfetoh El-Deeb and Mohamed Emara

Background: Coronary artery disease (CAD) is the single most common cause of death in the developed world, responsible for about one in every six deaths; 15.5 million person’s>20 years of age in the USA have coronary heart disease (CHD). No-reflow phenomenon defined classically as the lack of myocardial perfusion despite opening up the epicardial vessel in the setting of PPCI occurring in 10 % of cases of PPCI and associated with increase in 30 days mortality caused by multiple factors that lead to micro vascular obstruction and endothelial disruption by different mechanism like atherothrombotic embolization, ischemic injury, reperfusion injury and susceptibility of coronary microcirculation to injury.

Objective: The aim of the study to is to investigate the correlation between admission blood glucose level and the no-reflow phenomenon in patients with AMI undergoing Primary PCI.

Patients and methods: This study was Cross-sectional study which was conducted on patients presenting with acute ST segment elevation myocardial infarction who underwent primary PCI. The study included 280 patients presented with acute MI within less than 24 hours from onset of symptoms. All study population will undergo full medical history, full clinical examination, Blood sample and chemistry, electrocardiography, transthoracic echocardiography and coronary angiography.

Results: Admission hyperglycemia with AMI among AMI patients was independent predictor for incidence of no-reflow. Diabetics after classified into hyperglycemic and non-hyperglycemic, hyperglycemic in diabetics has significant high no-reflow rate compared to non-diabetics.

Conclusion: We established an association between hyperglycemia and the no-reflow phenomenon.