A Review on pharmaceutical and biomedical applications

Author(s): Cristina Stoicescu

The difficulty of treating damaged skin with conventional treatments and the rising incidence of skin diseases have prompted the creation of novel drug delivery systems for topical drug administration. Improved drug delivery features, such as controlled drug release, increased drug skin permeation and retention, and decreased systemic adverse effects, enable drug delivery systems to achieve these outcomes. For the treatment of skin conditions, natural polymers have proven to be useful excipients for incorporation into hybrid systems (nanocarriers dispersed in a semisolid base). Natural polymers have intrinsic bioactive properties that greatly enhance their applicability in drug delivery systems. These properties include being biocompatible, biodegradable, economical, easily available, and based on renewable resources. Chitosan, alginate, agarose, starch, hyaluronic acid, silk fibroin, collagen, and gelatin are just a few examples. These polymers also play a crucial role in the preparation of semisolid bases for cutaneous application, which improve the viscosity of formulations and, as a result, provide a suitable topical application for the management of skin diseases. Additionally, they play a crucial role in the preparation of polymeric nanoparticles, which increase skin penetration.