ISSN: 2044-9038 (Print) 2044-9046 (Electronic)

Clinical Practice

Toxicogenomics Online Journals

Toxicogenomics is a subdiscipline of pharmacology that deals with the collection, interpretation, and storage of facts approximately gene and protein interest within a specific mobile or tissue of an organism in reaction to exposure to toxic materials. Toxicogenomics combines toxicology with genomics or different high-throughput molecular profiling technology such as transcriptomics, proteomics and metabolomics. Toxicogenomics endeavors to elucidate the molecular mechanisms developed inside the expression of toxicity, and to derive molecular expression patterns (i.e., molecular biomarkers) that are expecting toxicity or the genetic susceptibility to it. In pharmaceutical research, toxicogenomics is described as the take a look at of the shape and function of the genome because it responds to unfavourable xenobiotic publicity. It’s far the toxicological subdiscipline of pharmacogenomics, that's extensively described as the examine of inter-person variations in entire-genome or candidate gene single-nucleotide polymorphism maps, haplotype markers, and changes in gene expression that would correlate with drug responses. Though the term toxicogenomics first regarded in the literature in 1999, it became by means of that point already in commonplace use in the pharmaceutical enterprise as its starting place became driven by using advertising techniques from vendor businesses. The time period is still now not universally typical, and others have supplied alternative terms which includes chemogenomics to describe essentially the identical discipline of examine.

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