Top Open Access Journals In Histopathology
Histopathology is the point at which autoimmune
hepatitis moves closer to the realm of
hepatology and organ-specific autoimmunity, and away from the multisystem autoimmune diseases. As indicated earlier (Chronic Active and Lupoid Hepatitis: Early Descriptions), the earlier clinical and histologic descriptions of “chronic active hepatitis” were virtually generic for all types of chronic
hepatitis and only in the 1970s was it realized that quite different liver diseases were encompassed within the ICD9 rubric 570.71, chronic active hepatitis. The availability of
liver biopsy samples led to numerous descriptions of the
histopathology of chronic active hepatitis, and these became formalized by reports from an International Group of Pathologists, 1969 and 1977; their recommendations provide the basis for current morphological criteria.
Histopathology of
tissues from animals that were perinatally infected and unable to clear the
infection develop chronic disease characterized by lymphocytic infiltration of the liver, lung, pancreas, kidney, spleen, meninges, and
brain (Genovesi and Peters, 1987; Oldstone and Dixon, 1969; Parker et al., 1976) as well as a chronic glomerulonephropathy and widespread vasculitis. The progressive
glomerulonephritis can be attributed to antigen–antibody complex deposition in the arterioles and glomerular basement membranes of the infected kidney.
Histopathology shows variably sized solid nodules of cuboid or columnar
cells of odontogenic epithelium arranged in nests, separated by minimal amounts of wispy fibrous connective tissue.
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