ISSN: 2041-6792

Clinical Investigation

Tissuechips Applications

Tissue chip devices are designed as accurate models of the structure and performance of human organs, like the lungs, liver and heart. Once developed and integrated, researchers can use these models to predict whether a candidate drug, vaccine or biologic agent is safe or toxic in humans during a faster and more effective way than current methods. The ultimate goal of the program is to accelerate the interpretation of basic discoveries into the clinic. By creating an integrated human body-on-a-chip, researchers can test the varied potential effects of a substance such as a drug across the entire body before any testing in humans. A small device that contains human cells during a 3D matrix represents an enormous leap within the ability of scientists to check how those cells answer stresses, drugs and genetic changes. About the dimensions of a thumb drive, the devices are referred to as tissue chips or organs on chips. The high rate of failure during drug development is well-known, however recent advances in tissue engineering and microfabrication have contributed to the event of microphysiological systems (MPS), or ‘organs-on-chips’ that recapitulate the function of human organs. These ‘tissue chips’ might be utilized for drug screening and safety testing to potentially transform the first stages of the drug development process.      

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