Stem Cell Research and Regenerative Medicine

Stem Cell Transplantation Scientific Journals

 Stem cell transplantation (SCT), sometimes mentioned as bone marrow transplant, may be a procedure during which a patient receives healthy stem cells to exchange damaged stem cells. Before SCT, the patient receives high doses of chemotherapy, and sometimes radiotherapy, to organize the body for transplantation. This is called "conditioning treatment." After the stem cells are infused into the patient’s bloodstream, they visit the bone marrow and start the method of forming new, healthy blood cells including white blood cells, red blood cells and platelets. This process is called “engraftment.” The main types of SCT are Autologous transplantation uses the patient’s own stem cells. These cells are removed, treated and returned to his or her own body after a conditioning regimen. Allogeneic transplantation uses stem cells from a donor. A donor may be a family member or someone who is not related to the patient. Reduced intensity stem cell transplantation. Like allogeneic transplant, the stem cells are from a healthy person (the donor), but the chemotherapy given is a smaller amount intensive. A syngeneic transplantation is much less common. Syngeneic transplantation is rare for the simple reason that it's only used on identical twins. In addition, the donor twin and therefore the recipient twin must have identical genetic makeup and tissue type.  

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