Stem Cell Research and Regenerative Medicine

Scholarly Journals In Tissue Transplantation

 Tissue or cell transplantation has been an extremely valuable technique for studying developmental potential of certain cell population, dissecting cell-environment interaction relationship, identifying stem cells, and many other applications. One key technical requirement for performing transplantation assay is that the capability of distinguishing the transplanted donor cells from the endogenous host cells, and tracing the donor cells over time. Zebrafish has emerged as a superb model organism for performing transplantation assay, because of the transparency of embryos during development and even certain adults. Using transgenic techniques and fast-evolving imaging technology, fluorescence labeled donor cells are often easily identified and studied in vivo. In this chapter, we'll first discuss the rationale of various sorts of zebrafish transplantation in both embryos and adults, then specialise in detailed methods of three types of transplantation: blastula/gastrula transplantation for mosaic analysis, somatic cell transplantation, and tumor transplantation. Tissue transplantation therapy, which has been utilised for over 50 years, is a rapidly developing field carrying with it great promise for ameliorating or curing many diseases. One of its drawbacks, however, is the potential for donor-to-recipient disease transmission. This risk is greatly reduced by excluding donors at risk of carrying infection and by testing the donor for transmissible infectious disease.  

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