ISSN: 2044-9038 (Print) 2044-9046 (Electronic)

Clinical Practice

Positive Strand RNA Infection Top Open Access Journals

Single stranded RNA viruses are often classified consistent with the sense or polarity of their RNA into negative-sense and positive-sense, or ambisense RNA viruses. Positive-sense viral RNA is analogous to mRNA and thus are often immediately translated by the host cell. Negative-sense viral RNA is complementary to mRNA and thus must be converted to positive-sense RNA by an RNA polymerase before translation. As such, purified RNA of a positive-sense virus can directly cause infection though it's going to be less infectious than the entire virus particle. Purified RNA of a negative-sense virus isn't infectious by itself because it must be transcribed into positive-sense RNA; each virion are often transcribed to many positive-sense RNAs. Ambisense RNA viruses resemble negative-sense RNA viruses, except they also translate genes from the positive strand. a standard viral positive-strand RNA viruses that infect humans are the picornaviruses.

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