Perineural Invasion Scholoarly Peer-review Journal

 Perineural invasion, refers to cancer invasion of the nerve-encompassing space. It is common in neck and head cancer, colorectal cancer and prostate cancer. Cancer with PNI usually has a worse prognosis, since PNI is thought to indicate perineural proliferation, which can make it difficult to resect malignant lesions. In prostate cancer, PNI in needle biopsies is a poor prognosticator; However, in prostate specimens, it is unclear if it has a worse prognosis. One study found that PNI was found in about 90% of the radical samples of the prostate, and PNI outside the prostate, in particular, was associated with worse prognosis. However, there are controversies over whether PNI has a prognostic significance for cancer malignancy.    

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