Open Access Articles On Alkaloids
Alkaloids are a category of present organic compounds that mostly contain basic nitrogen atoms. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of comparable structure can also be termed alkaloids. In addition to carbon, hydrogen and nitrogen,
alkaloids can also contain oxygen, sulfur and, more rarely, other elements like chlorine, bromine, and phosphorus.
Alkaloids are produced by an outsized sort of organisms including bacteria, fungi, plants, and animals. They can be purified from crude extracts of those organisms by acid-base extraction, or solvent extractions followed by silica-gel
chromatography .
Alkaloids have a good range of pharmacological activities including antimalarial (e.g. quinine), antiasthma (e.g. ephedrine), anticancer (e.g. homoharringtonine),[8] cholinomimetic (e.g. galantamine), vasodilatory (e.g. vincamine), antiarrhythmic (e.g. quinidine), analgesic (e.g. morphine), antibacterial (e.g. chelerythrine), and antihyperglycemic activities (e.g. piperine). [failed verification] Many have found use in traditional or modern medicine, or as starting points for drug discovery. Other
alkaloids possess psychotropic (e.g. psilocin) and stimulant activities (e.g. cocaine, caffeine, nicotine, theobromine), and have been used in entheogenic rituals or as recreational drugs.
Alkaloids can be toxic too (e.g. atropine, tubocurarine). Although
alkaloids act on a diversity of metabolic systems in humans and other animals, they almost uniformly evoke a bitter taste.
High Impact List of Articles
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Predicting exacerbation in young children with intermittent asthma
Stefan Zielen*, Martin Christmann, Sophie von Erffa, Martin Rosewich, Markus Rose & Johannes Schulze
Research Article: Clinical Practice
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Predicting exacerbation in young children with intermittent asthma
Stefan Zielen*, Martin Christmann, Sophie von Erffa, Martin Rosewich, Markus Rose & Johannes Schulze
Research Article: Clinical Practice
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Pharmacotherapy of bipolar disorder: current status and emerging options
EKL Sandlin, Y Gao, RS El-Mallakh
Review Article: Clinical Practice
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Pharmacotherapy of bipolar disorder: current status and emerging options
EKL Sandlin, Y Gao, RS El-Mallakh
Review Article: Clinical Practice
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The lower safety level of blood pressure evaluated by 123I‑IMP single-photon emission computed tomography in acute cerebral infarction patients
Taizen Nakase, Shotaroh Yoshioka, Masahiro Sasaki, Akifumi Suzuki
Research Article: Clinical Practice
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The lower safety level of blood pressure evaluated by 123I‑IMP single-photon emission computed tomography in acute cerebral infarction patients
Taizen Nakase, Shotaroh Yoshioka, Masahiro Sasaki, Akifumi Suzuki
Research Article: Clinical Practice
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Nilotinib for treatment of chronic myeloid leukemia in light of the current evidence and guidelines
Pratap Neelakantan, Jane F Apperley
Review Article: Clinical Practice
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Nilotinib for treatment of chronic myeloid leukemia in light of the current evidence and guidelines
Pratap Neelakantan, Jane F Apperley
Review Article: Clinical Practice
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Author guidelines: Volume 8 Issue 4
Appendices: Clinical Practice
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Author guidelines: Volume 8 Issue 4
Appendices: Clinical Practice
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