ISSN: 2041-6792

Clinical Investigation

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 Next generation sequencing (NGS), massively parallel or deep sequencing area unit connected terms that describe a DNA sequencing technology that has revolutionised genomic analysis. mistreatment NGS a whole human ordination may be sequenced among one day. In distinction, the previous Sanger sequencing technology, accustomed deciphers the human ordination, needed over a decade to deliver the ultimate draft. Though in ordination analysis NGS has largely outdated typical Sanger sequencing, it's not however translated into routine clinical observe. The aim of this text is to review the potential applications of NGS in medical specialty.   There are a unit variety totally different of NGS platforms mistreatment different sequencing technologies, a close discussion of that is on the far side the scope of this text. However, all NGS platforms perform sequencing of countless tiny fragments of DNA in parallel. Bioinformatics analyses area unit accustomed piece along these fragments by mapping the individual reads to the human reference ordination. Every of the 3 billion bases within the human ordination is sequenced multiple times, providing high depth to deliver correct knowledge and an insight into sudden DNA variation. NGS may be accustomed sequence entire genomes or unnatural to specific areas of interest, as well as all twenty two 000 cryptography genes (a whole exome) or tiny numbers of individual genes.

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