Neurodegenerative Disorders Journals
Neurodegeneration is that the progressive loss of structure or function of neurons, including death of neurons. Many
neurodegenerative diseases – including amyotrophic lateral sclerosis, paralysis agitans , Alzheimer's disease , fatal familial insomnia, and Huntington's chorea – occur as a results of
neurodegenerative processes. Such diseases are incurable, leading to progressive degeneration and/or death of neuron cells. As research progresses, many similarities appear that relate these diseases to at least one another on a sub-cellular level. Discovering these similarities offers hope for therapeutic advances that would ameliorate many diseases simultaneously. There are many parallels between different
neurodegenerative disorders including atypical protein assemblies also as induced necrobiosis .
Neurodegeneration are often found in many various levels of neuronal circuitry starting from molecular to systemic. Alzheimer's disease is characterized by the loss of
neurons and synapses within the cerebral mantle and certain subcortical regions. This loss leads to gross atrophy of the affected regions, including degeneration within the lobe and lobe , and parts of the frontal area and gyrus cinguli .Comparison of
brain tissue between healthy individual and Alzheimer's disease patient, demonstrating extent of neuronal deathAlzheimer's disease has been hypothesized to be a protein misfolding disease (proteopathy), caused by accumulation of abnormally folded A-beta and tau proteins within the brain.
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