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Clinical Investigation

Leading Journals On Diabetes Mellitus Type 1

 Type 1 diabetes may be a disease during which the body doesn't make enough insulin to regulate blood glucose levels. Type 1 diabetes was previously called insulin-dependent diabetes or type I diabetes. During digestion, food is weakened into basic components. Carbohydrates are weakened into simple sugars, primarily glucose. Glucose is a critically important source of energy for the body's cells. To provide energy to the cells, glucose must leave the blood and obtain inside the cells. Insulin traveling in the blood signals the cells to take up glucose. Insulin is a hormone produced by the pancreas. When levels of glucose within the blood rise, like following a meal, the pancreas normally produces more insulin. Type 1 diabetes occurs when some or all of the insulin-producing cells within the pancreas are destroyed. This leaves the patient with little or no insulin. Without insulin, sugar accumulates within the bloodstream instead of entering the cells. As a result, the body cannot use this glucose for energy. In addition, the high levels of glucose that remains in the blood cause excessive urination and dehydration, and damage tissues of the body. Type 1 diabetes is an autoimmune disease. This means it begins when the body's immune system attacks cells in the body. In type 1 diabetes, the system destroys insulin-producing cells (beta cells) within the pancreas.  

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