ISSN: 2041-6792

Clinical Investigation

Hepatic Steatosis Impact Factor

 As organs shortage was anticipated as early as 1987, the development of what is called “marginal donors” was crucial.1 A marginal graft could be defined as an organ with an increased risk for poor function or failure that may subject the recipient to higher risks of morbidity or mortality. However, there is no consensus about factors that define a graft as marginal and should be excluded from the use because of unacceptable risk to the recipient. Therefore, the decision to transplant a specific organ depends on the judgment of the transplant surgeon and consideration of the specific recipient.2 Broadly there are two categories of marginal grafts. Firstly, there are grafts which carry a high risk of technical complications and/or impaired function, including the steatotic livers, non-heart beating donors, elderly donors, split livers, donors with high inotrope requirement or long ischaemia times. Secondly, grafts will be considered marginal if they carry a risk of transmission of infection and/or malignancy to the recipient. Among the wide range of these ECD livers, hepatic steatosis is one of the most frequent disorders, which is mostly related to an increasing prevalence of fatty liver diseases. Fatty liver is defined as the fat accumulation of at least 5% of liver weight in the absence of other etiologies of liver disease or use of steatogenic medication. Traditionally, fatty disorders of the liver have been classified into alcoholic and non-alcoholic.  

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