Gene-silencing

The epigenetic modification of genes causing inactivation of previously active genes or chromosomes os called gene silencing. Changes in DNA methylation and covalent modification of histone proteins are the cause for gene repression, which can also cause chromatin compaction. mRNA degradation may cause gene silencing post transcription also. Small RNA regulator such as micro RNAs , small interfering RNAs and Piwi RNAs generated from double stranded RNAs can moderate these effects. Various method of gene silencing are increasingly used in therapeutics to treat cancer and other infectious diseases. There are three types of gene silencing namely transcriptional, post transcriptional and meiotic.

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