Epithelial Mesenchymal Transition Peer Review Journals
Epithelial–mesenchymal transition (EMT) may be a cellular programme that's known to be crucial for embryogenesis, wound healing and malignant progression. During EMT, cell–cell and cell–extracellular matrix interactions are remodelled, which results in the detachment of epithelial
cells from one another and therefore the underlying basement membrane, In the context of neoplasias, EMT confers on
cancer cells increased tumour-initiating and metastatic potential and a greater resistance to
elimination by several therapeutic regimens. In this Review, we discuss recent findings on the mechanisms and roles of EMT in normal and neoplastic tissues, and the cell-intrinsic signals that sustain expression of this programme. We also highlight how EMT gives rise to a variety of intermediate cell states between the epithelial and the mesenchymal state, which could function as
cancer stem cells. In addition, we describe the contributions of the tumour microenvironment in inducing EMT and the effects of EMT on the immunobiology of carcinomas. Epithelial–mesenchymal transition (EMT) may be a cellular mechanism long recognized as a central feature of normal development. Several developmental milestones, including gastrulation, neural crest formation and heart morphogenesis, believe the plastic transition between epithelium and mesenchyme
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