Drug Distribution Top Open Access Journals
Drug Distribution meant the reversible amount of drug transferred from one part to another part inside the body. When a drug enters into systemic circulation by absorption, it is distributed into interstitial and intracellular fluids. The organ or tissue receives different quantity of drug doses and the drug is remained in the different organs or
tissues for a variable amount of time. The distribution of a drug doses between
tissues is reliant on vascular permeability, cardiac output, regional blood flow and perfusion rate of the tissue and the binding of drug to tissue and plasma proteins and its lipid solubility. pH partition also takes part in drug distribution. In highly perfused organs such as the liver, heart and kidney
Drugs can be easily distributed. At perfused
tissues like muscle, fat and peripheral organs
drugs is distributed in small quantity. when the equilibrium is known the unbound drug present in plasma is distributed from the plasma to the tissue. Distribution in
Pharmacology is a branch of
pharmacokinetics that describes the reversible transfer of one drug from one body to another. Once a drug enters the systemic circulation by absorption or direct administration, it must be distributed in the interstitial and intracellular fluids. Each organ or tissue can receive different doses of the drug, and the drug can stay in a variable amount of time for different organs or tissues. The distribution of a drug between
tissues depends on vascular permeability, regional blood flow, tissue perfusion rate and the ability of the drug to bind tissue and plasma proteins to lipid solubility. The pH partition also plays a major role. The drug is easily distributed in highly perfused organs such as the liver, heart and kidneys. It is distributed in small, less perfused
tissues such as muscles, fats and peripheral organs.
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