ISSN: 2044-9038 (Print) 2044-9046 (Electronic)

Clinical Practice

Drug Distribution Case Reports Journals

 Drugs are going to be more quickly distributed to areas of the body that receive large amounts of blood flow (e.g. heart, kidneys) than to areas that receive little blood flow (e.g. skin, adipose). On the opposite hand, once a drug reaches fat , it's going to remain distributed here for quite a while until plasma concentrations decline and therefore the drug can move “down its concentration gradient” back to the blood stream (e.g. “re-distribution”). The concept of “apparent volume of distribution” is a concept that seeks to predict how extensively a drug is distributed throughout the body. The apparent volume of distribution, Vd, is mathematically calculated by dividing the dose that is administered (mg) by the plasma concentration (mg/L).There are four interactive modules that allow users to get a better understanding of VD. The first is a simple container in which learners can “inject” drug into different containers and view what happens to drug concentration and see how this relates to volume. In the second module, users can inject drug and see what happens as drug distributes more widely throughout various compartments. The third module relates VD concepts to the human body; for drugs with an outsized VD, users can observe how drugs distribute outside the bloodstream whereas drugs with a small VD stay mainly in the vasculature.  

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