Cell Migration Journals

Synthetic extracellular matrices give a framework during which cells are often exposed to outlined physical and biological cues, but no methodology exists these days to control single cells inside these matrices to grasp elementary principles of cell migration and outline conditions that support or inhibit cell movement. Here, we tend to gift a method for manipulating individual class stem cells in outlined artificial hydrogels through selective optical activation of Rac. an evident optical device was applied to guide directional migration of class stem cells in poly(ethylene glycol), PEG, primarily based gel networks incorporated with associate degree adhesion amide matter, Tyr-Arg-Gly-Asp-Ser (YRGDS). Mesenchymal stem cells (MSCs) were transfected with a genetically encoded photoactivatable Rac1 (PA-Rac).      

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