Stem Cell Research and Regenerative Medicine

Cell Line Top Open Access Journals

Cell lines are often utilized in place of primary cells to review biological processes. However, care must be taken when interpreting the results as cell lines don't always accurately replicate the first cells. We will  quickly make reference to focal points and disadvantages of cell lines at that point talk about outcomes utilizing the mouse Sertoli cell line, MSC-1, compared with primary mouse Sertoli cells. MSC-1 cells resemble Sertoli cells morphologically and possess several biochemical markers related to Sertoli cells. Studies have demonstrated that the function and regulation of retinoic acid receptor α (RARα) is analogous between MSC-1 and rat Sertoli cells. However, MSC-1 cells lack a number of the immune privilege properties related to primary Sertoli cells, including survival in animals with a totally functional system . Therefore, it's to be kept in mind that cell lines don't behave identically with primary cells and will not be wont to replace primary cells. In order to strengthen the findings, key control experiments using primary cells should always be performed.  They offer several advantages, such as they are cost effective, easy to use, provide a boundless flexibly of material and sidestep moral concerns related with the utilization of creature and human tissue.    

High Impact List of Articles

Relevant Topics in Material Science