Stem Cell Research and Regenerative Medicine

Cell Line Research Articles

quality of the medium and therefore the cell preparation technique are vital for the upkeep of human epithelial cells in culture. By employing a defined medium and cell separation technique, human pancreatic epithelial cells are kept in culture for quite 10 months. Another, recently discovered method to prolong the lifetime of human cell is that the infection of cells with telomerase, an enzyme that forestalls telomere loss by de novo addition. It restores the length of telomeres, which otherwise shorten with each cell proliferation, resulting in senescence. So far, successful reports include immortalized fibroblasts and retinal and endothelial cells. Attempts are made to spot and culture stem cells of specific tissues because these cells can better suits the environmental conditions and may produce to a spread of mature cells under specific environments. For instance , it's been shown that cultured colon cells containing stem cells can produce to either neuroendocrine cells, colon cells, or a mix of them. Therefore, such cultures provide ample opportunity to research differentiation pathways and supply a singular tool to check the consequences of natural and artificial substances, including cytokines, growth factors, nutrients, and physical factors within the maturation or death of the cells. The mechanisms of malignant transformation are often studied in vitro using cell lines treated with a carcinogen or radiation in culture.    

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