Stem Cell Research and Regenerative Medicine

Bone Marrow Open Access

Premature deliveries account for 10 per cent of live births in the US and premature infants' survival has improved over the years with perinatal and neonatal care advances. Nearly 25-30 per cent of premature infants with a birth weight of less than 1250 grams develop bronchopulmonary dysplasia (BPD) characterized by abnormal alveolar and vascular development during a critical postnatal lung development stage. Animal BPD models suggest that abnormal lung microvascular development leads to the failure of alveolar development and vascular development strategies result in improved lung alveolarization .In addition, low levels of bone marrow-derived and circulating endothelial progenitors have been observed in the blood of exposed neonatal mice with hyperoxia that develop BPD, indicating that endothelial progenitors derived from bone marrow that play a role in neonatal lung growth.

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