ISSN: 2044-9038 (Print) 2044-9046 (Electronic)

Clinical Practice

Biotransducer

            Biotransducers are components for the detection of biosensor detection systems. It consists of two parts which are tightly connected. The biological detection layer and the physics-chemical converter that work together convert biochemical signals into electronic or optical signals. The biological recognition layer usually contains enzymes or other binding proteins such as antibodies. Oligonucleotide sequences, subcellular fragments such as organelles (eg mitochondria) and receptor fragments (eg cell walls), individual intact cells, small numbers of synthetic skeletal cells or thin slices of animal or vegetable tissue can also contain biological recognition layers from biosensors. Physicochemical transducers are usually in close contact and controlled by the detection layer. Due to the presence and biochemical effects of the analyte (the target of interest), physicochemical changes in the biocognition layer are obtained, which are measured by physicochemical transducers and produce a signal that is proportional to the concentration of the analyte. Physics-chemistry converters can be electrochemical, optical, electronic, gravimetric, pyroelectric, or piezoelectric. Based on the type of biotransductor, biosensors can be classified as shown on the right.

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