Stem Cell Research and Regenerative Medicine

Articles On Root Sheaths

 The follicle may be a tubular epithelial structure opening on to the epidermal surface. This is often richly furnished with myelinated and non-myelinated nerve endings and abundant small blood vessels. The interior root sheath of the follicle consists of three layers: Henle's layer, which may be a single cell layer. A thicker layer characterized by the presence of huge eosinophilic trichohyalin granules. The cuticle, which consists of overlapping keratin plates. The cuticle is continuous with the cuticle of the hair shaft (see below) within the lower regions of the follicle. the interior root sheath undergoes keratinization to supply the hair shaft. It extends up from the hair bulb to about the extent of the insertion of the sebaceous glands, where it disintegrates, leaving a possible space round the hair shaft into which the sebaceous follicle products are secreted. Near the opening of the follicle on to the skin surface, it consists of all three epidermal layers (basal, skin cell and granular). within the deeper parts of the follicle, below the purpose of insertion of the sebaceous glands, it's composed of highly modified prickle cells, with large, pale-staining cells rich in glycogen. Outside the external root sheath may be a thick basement membrane, which is strongly eosinophilic

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