ISSN: 2041-6792

Clinical Investigation

Academic Journals In Histology

Histology has always played an important role in diagnosis and subsequent treatment options. The advent of molecular testing can evaluate a patient’s overall outcome (prognosis) or identify whether a patient qualifies for a specific therapy (predictive), making it imperative to produce the highest quality tissues. Standardization of the fixation and processing of tissue has become a focus due to the increased use of companion diagnostics. Pre-analytic, analytic and post-analytic variables are addressed in the published guidelines for tests linked to companion drug treatments. The requirements given ensure accurate demonstration of prognostic markers. The pressures to comply with the new standards and guidelines are forcing histology laboratories to revisit their processing schedules and adapt or adjust protocols accordingly. Histologic techniques incorporate various histochemical stains. The goal is to visualize the neurons, axons, various supportive cells, and myelin while using the histologic techniques. The initial staining used to give an overview of the tissue is generally hematoxylin and eosin. The hematoxylin dye visualizes the nuclei whereas the eosin dye visualizes the cytoplasm. By assessing the hematoxylin and eosin-stained sections, an overview of the normal morphology and type and distribution of the different cells can be determined. Furthermore, various alterations in the morphology and cells can eventually be seen.    

High Impact List of Articles

Relevant Topics in Clinical