Commentary - Stem Cell Research and Regenerative Medicine (2022) Volume 5, Issue 3

Regeneration of Hair Cells: Making Sense of All the Noise

Bernd K Fritzsch*

Department of Biology, University of Iowa, Iowa City, IA, 52242, USA

*Corresponding Author:
Bernd K Fritzsch Department of Biology, University of Iowa, Iowa City, IA, 52242, USATel: +1-311-353-8769.E-mail:

Received: 02-Jun-2022, Manuscript No. srrm-22-17806; Editor assigned: 06-Jun-2022, PreQC No. srrm-22- 17806 (PQ); Reviewed: 20-Jun-2022, QC No. srrm-22-17806; Revised: 23-Jun-2022, Manuscript No. srrm-22- 17806 (R); Published: 30-Jun-2022, DOI: 10.37532/srrm.2022.5(3).53-54


Hearing loss affects hundreds of millions of people worldwide by dampening or cutting off their audile connection to the world. Current treatments for sensor ineural hail loss (SNHL) with cochlear implants aren’t perfect, leaving regenerative drug as the logical avenue to a perfect cure. Advancements in our molecular understanding of the minimum essential genes necessary for hair cell conformation and recent advances in stem cell manipulation, similar as seen with inducible pluripotent stem cells (iPSCs) and epidermal neural crest stem cells (EPI- NCSCs), have opened new possibilities to advance exploration in translational stem cell curatives for individualities with hail loss [1]. Despite this, more detailed network charts of gene expression are demanded, including an appreciation for the places of microRNAs (miRs), crucial controllers of transcriptional gene networks. To harness the true eventuality of stem cells for hair cell rejuvene science, introductory wisdom and clinical drug must work together to expedite the transition from bench to bedside by expounding the full mechanisms of inner observance hair cell development, including a focus on the part of miRs, and conforming this knowledge safely and efficiently to stem cell technologies [2]


iPSCs• miRNAs • stem cells• hair cells• rejuvenescence• EPI- NCSCs


Sensorineural hail loss (SNHL) afflicts over 278 million individualities worldwide and nearly half of all individualities over the age of 65. This multifactorial complaint results from gene mutations, ototoxic medicines, environmental cuts, or aging, and is frequently unrecoverable. Hearing loss imparts a substantial fiscal cost to society and bears an emotional and quality of life burden to the affected existent along with his/ her family. While forestallment of hail loss through protection of hair cells is ideal, it isn’t always possible, leaving regenerative drug the sole partner post facto option for a endless and restorative treatment of hail loss [3]. Still, rejuvenescence of damaged sensitive epithelia in the mammalian inner observance is complicated as discerned adult inner observance neurosensory towel can not re-up the cell cycle and be used to replace neighboring cells, as is spontaneously fulfilled innon-mammalian systems [4]. This absence of proliferative capacity necessitates the use of exogenous stem cells as a medium for hair cell restoration, unless possibilities are discovered to jumpstart adult neurosensory epithelia proliferation. In vitro attempts using stem cells have been initiated to reconstitute hair cells in the murine system and have been shown to be able of secerning into hair cell like cells. Still, despite great advances, it’s apparent that we don’t relatively understand the molecular base of hair cell development in vitro or in vivo or have the capability to control the placement of stem cells and/ or hair cell precursors to damaged towel [5].


With the dawn of gene remedy and technological thunderclaps in stem cell technology, regenerative drug appears to be the surge of the future, promising cures to a wide array of mortal conditions. While regenerative drug is still in its immaturity and times down from clinical adaption, it represents new relations between introductory scientists and clinicians [6]. Unknown in connection, rejuvenescence of any towel requires a solid foundational knowledge of the molecular base of experimental processes and stem cell regulation. Millions of cases suffer from hail loss performing from lost hair cells in the organ of Corti. Gene remedy and stem cells may offer a endless cure for tormented individualities, but the complexity of the observance compared to other systems, makes rejuvenescence of hair cells a daunting task. Yet, the once ten times have shown an inconceivable advancement in the molecular understanding of observance development. A uninterrupted enhancement in understanding of observance development composite with the continuous advancements of gene remedy and stem cell biology may eventually be fine- tuned music to the cognizance of numerous [7].



Conflict of Interest

No conflict of interest


  1. Pauley S, Kopecky B, Beisel K, Soukup G, Fritzsch B et al. Stem cells and molecular strategies to restore hearing. Panminerva Med, 50, 41-53(2008).
  2. Indexed at, Google Scholar

  3. Oshima K, Suchert S, Blevins NH, Heller S et al. Curing hearing loss: Patient expectations, health care practitioners, and basic science. J Commun Disord, 43, 311-318(2010).
  4. Indexed at, Google Scholar, Crossref

  5. Jongkamonwiwat N, Zine A, Rivolta MN. Stem cell based therapy in the inner ear: Appropriate donor cell types and routes for transplantation. Curr Drug Targets, 11, 888-897(2010).
  6. Indexed at, Google Scholar, Crossref

  7. Brigande JV, Heller S. Quo vadis hair cell regeneration? Nat. Neurosci, 12, 679-685(2009).
  8. Indexed at, Google Scholar, Crossref

  9. Stucky SR, Wolf KE, Kuo T. The economic effect of age-related hearing loss: National, state, and local estimates, 2002 and 2030. J Am Geriatr Soc, 58, 618-619(2010).
  10. Indexed at, Google Scholar, Crossref

  11. Peterson NR, Pisoni DB, Miyamoto RT. Cochlear implants and spoken language processing abilities: Review and assessment of the literature. Restor Neurol Neurosci, 28, 237-250(2010).
  12. Indexed at, Google Scholar, Crossref

  13. Chang YP, Fu QJ. Effects of talker variability on vowel recognition in cochlear implants. J Speech Lang Hear Res, 49, 1331-1341(2006).
  14. Indexed at, Google Scholar, Crossref

Awards Nomination 20+ Million Readerbase

Select your language of interest to view the total content in your interested language

Google Scholar citation report
Citations : 32

Stem Cell Research and Regenerative Medicine received 32 citations as per Google Scholar report

Stem Cell Research and Regenerative Medicine peer review process verified at publons

Indexed In