Abstract

Thrombosis Management in Healthcare

Author(s): Vidhya Meleveetil

T hrombosis condition is a serious aspect in healthcare management. It is involved in conditions arising from pharmacological interventions and Mechanical Circulatory and Respiratory Support (MCRS) devices. The conditions involve blood clot formation, and can be a cause of stroke, myocardial infarction or deep vein thrombosis. P2Y12 receptor is studied extensively in analysing platelet aggregation. Structurally validation confirms the stability of receptor. The intraprotein interaction studies highlight crucial residues essential for ligand binding. Natural ligands have demonstrated comparable interactions with P2Y12, offering potential ligands in place of other drugs which could promote fewer side effects. Thrombosis can be manged through advancements in receptor-targeted therapies, combined with novel ligand discoveries. This would ensure safer and more effective treatment strategies. Continued research in this domain is vital for optimizing anticoagulation therapies and improving long-term patient outcomes.