Relationship of mean arterial pressure with other cardiac and biological factors

Author(s): Shipra Banik*, Mahashweta Das, Sunit Kumar Medda, Rabindra Nath Das

Objective: The relationship of Mean Arterial Pressure (MAP) with the other cardiac and biological factors is very complicated, and is not well-known in the literature. The report focuses on the associations of MAP with other cardiac and biological factors for shock patients.

Material & Methods: A real data set of 113 shock patients with 20 study variables is considered in the report, which is available on the site http://www.umass.edu/statdata/statdata/data/ shock.txt. The probabilistic model of MAP has been derived using statistical joint generalized linear models.

Results: The MAP is positively associated with age (P=0.0065), systolic blood pressure (SBP) (P<0.0001), diastolic blood pressure (DBP) (P<0.0001), cardiac index (CI) (P<0.0001), joint interaction effects of heart rate (HR) & mean central venous pressure (MCVP) (HR*MCVP) (P=0.0288), DBP*MCVP (P=0.0022), body surface index (BSI)*MCVP (P=0.0337), SBP*BSI (P=0.0472), while it is negatively associated with survival status (Survive) (P=0.0127), MCVP (P=0.0004), BSI (P=0.0048), appearance time (AT) (P=0.0379), hematocrit (HCT) (P=0.0988), SBP*HR (P=0.0039) and SBP*DBP (P<0.0001). Variance of MAP is negatively associated with sex (P=0.0279), shock type at level 2 (P=0.0367), at level 3 (P=0.0012), SBP (P=0.0342), DBP (P<0.0001), BSI (P<0.0001), DBP*MCVP (P=0.0482), while it is positively associated with SBP*DBP (P=0.0004), DBP*BSI (P<0.0001) and HCT (P=0.0703).

Conclusion: MAP is higher at older ages. It increases if SBP, or DBP, or CI, or HR*MCVP, or DBP*MCVP, or MCVP*BSI, or SBP*BSI increases. It decreases if MCVP, or BSI, or AT, or HCT, or SBP*HR, or SBP*DBP increases.