Novelties in additive manufacturing and bioprinting

Author(s): Luciano Pitzurra

The use of autologous materials such as platelet-rich fibrin (PRF) and advanced platelet-rich fibrin (A-PRF+) for enhancing wound healing and repairing damaged tissue is a reality. Patient’s own blood can be processed without addition of anticoagulants in order to obtain a tridimensional fibrin network containing platelets and leukocytes (including monocytes, lymphocytes, and granulocytes) that can act as a scaffold in the early phases of wound healing. It is reported that the interaction between these cells and the fibrin matrix stimulates a slow release of growth factors that may result in a better wound healing in the early phase of this process. PRF’s derivatives are widely used in oral surgery and periodontology. Bone defects in the patient’s jaws can be repaired, the wound healing can be improved. In vitro and in vivo studies shows advantages of these autologous materials in cells behavior and clinical wound healing outcome, but clinicians must be as well aware of their limitations.