Lung Side Effects of Non-Steroidal Anti Inflammatory Drugs in Neonates

Author(s): Karel M Allegaert

Non-steroidal anti-inflammatory medicines like ibuprofen or indomethacin are generally specified medicines to induce pharmacologic check of a patent ductus arteriosus in preterm babes. Grounded on a lately published Cochrane meta- analysis, both medicines are inversely effective to induce check. Medicine choice can thus be grounded on differences in side goods or pharmacology - profitable arguments. The current review quantifies the negative impact of either ibuprofen or indomethacin on renal function, including diuresis, glomerular filtration rate and renal tubular function. Both ibuprofen and indomethacin have a quantifiable impact on renal function. Still, compared to ibuprofen, the negative impact of indomethacin is more pronounced.