Immunity regulation and bone marrow

Author(s): Chritiana William*

The primary hematopoietic organ is assumed to be bone marrow. However, evidence suggests that immune cells such as regulatory T cells, conventional T cells, B cells, dendritic cells, Natural Killer T (NKT) cells, neutrophils, myeloid-derived suppressor cells, and mesenchyme stem cells have active function and trafficking in the bone marrow. Furthermore, multiple human cancers have a preset metastatic site in bone marrow. The immunological network in the bone marrow is discussed in this review. We believe that bone marrow is an immune regulatory organ that can fine-tune immunity, and that it could be a therapeutic target for immunotherapy and immune vaccination.