Drug interaction between the Carbamazepine and phenytoin

Author(s): Sam Candeloro

Carbamazepine and phenytoin are powerful inducers of compounds that process oral anticoagulants. to determine whether these anticonvulsants’ drug-drug interactions with oral anticoagulants have an effect on treatment with DOACs or vitamin K antagonists, as well as their clinical impact. Patients receiving carbamazepine or phenytoin in addition to anticoagulants had a significantly higher risk of developing thromboembolism. VKA patients and DOAC patients had similar rates of thrombotic and bleeding events. In 47% of the cases examined, DOAC levels were lower than anticipated and did not correlate with clinical outcomes.