Dose the simultaneous treatment of radiation therapy and immunotherapy accelerate the cardiac toxicity?

Author(s): Yi Lu

Multiple studies have reported that both radiation therapy and immunotherapy can cause cardiac toxicity. In a combined analysis of four consecutive, prospective multicenter RT trials for locally advanced NSCLC, the 24-month cumulative incidence of grade ≥ 3 cardiac events were observed to be as high as to 11%. Another post hoc analysis of six prospective trials in locally advanced NSCLC revealed that 23% of patients experienced one or more symptomatic cardiac events.