Chorioamnionitis associated outcomes of Neonates

Author(s): Alex Christian

Chorioamnionitis or intra-uterine irritation is an incessant reason for preterm birth. The majority of the developing fetus’s organs can be affected by chorioamnionitis. Chorioamnionitis has been linked to a variety of microbes, but “sterile” inflammation seems to be more prevalent. Because inflammatory mediators continue to cause injury to the fetus and mother, it has not been demonstrated that eradicating microorganisms will prevent the morbidity and mortality that are associated with chorioamnionitis. The idea that the subsequent neonatal immune dysfunction is a reflection of the effects of inflammation on immune programming during crucial developmental windows, resulting in chronic inflammatory disorders and vulnerability to infection after birth, is now supported by accumulating evidence. Infants born to mothers with chorioamnionitis may benefit from better treatment options if we have a better understanding of how the microbiome changes and how inflammatory dysregulation occurs.