An examination of persistent Stem cells dysfunctionAuthor(s): Ajay Kumar Mishra*
Accidental stroke is a rare cerebrovascular disease, with recurrent accidental and hemorrhagic strokes and severe neurological deficits in young patients. The etiology of MMA is still unknown. The onset of disease in a large number of pediatric cases raises questions about the role of genetic factors in disease etiology. The clinical course or progression of MMA in these patients is largely unknown. By generating comprehensive molecular and cellular profiles of plasma and CSF from pediatric MMA patients, our study provides insights into the levels of circulating endothelial progenitor cells (cEPCs), the pathogenesis of MMA, and the selection of early stages of disease. Offers. The aim is to elucidate the induced protein release. Cytofluorometry and immunoassays were used in pediatric MMA patients and compared with controls by age and sex. Elevated cEPC levels in peripheral blood and upregulation of angiogenic markers (ie, angiopoietin-2 and VEGF-A) in CSF were observed. This finding is probably related to the deregulation of angiogenesis, indicated by moderate development of the collateral network (Suzuki III-IV). The lack of significant neurofilament light modulation in the cerebrospinal fluid allowed us to rule out the presence of significant neuronal damage in children with MMA. Despite our limited cohort of pediatric patients, we found several unique cellular and molecular features in blood and CSF samples. Our results are supported by a more comprehensive and prospective study to identify predictive or prognostic circulating biomarkers and potential therapeutic targets for personalized care in pediatric MMA patients.