Advances in fetal congenital heart disease (FCD) gene research and diagnostic testing

Author(s): Rabindra Vedi

Congenital Heart Disease (CHD), a type of congenital malformation, is a polygenic disease that is related to several major genes and is related to environmental factors. Advancements in science and technology have led to advances in the study of genetic patterns as well as testing methods. To understand how each gene contributes to normal and pathological anatomies, CHD research has been a major goal. We reviewed the development of testing methodologies and CHD related genes to provide some insights for the prenatal diagnosis of CHD and hope to achieve intervention and treatment of CHD at the gene level in the near future. The congenital heart disease is a congenital malformation that occurs during human embryonic development and is a common cause of death in new-borns. The incidence rate of CHD is estimated to be 4 ‰ – 5‰, and the internationally recognized birth rate is about With the development of ultrasound and paediatric cardiac surgery, it can be diagnosed during pregnancy and treated surgically after delivery.