Abstract

A Prospective Study and Meta-Analysis of Fetal Stem cells Mesenchymal Stem Cell Implantable devices for the Cure of Inflexion Chondral Abnormalities

Author(s): Snigdha Yadav

Osteoarthritis is still a terrible long-term result of knee focal cartilage defects. It has necessitated the investigation of new treatments to regenerate cartilage before significant deterioration and subsequent joint replacement occur. It is associated with functional loss and pain. Polymer scaffold compositions and a wide range of mesenchymal stem cell (MSC) sources has been the subject of recent research. It is unclear how various combinations affect the quality of newly formed cartilage as well as the degree of integration between native and implant cartilage. In vitro and animal studies have largely demonstrated that implants seeded with bone marrow-derived MSCs (BMSCs) can restore these defects. Systematic review and meta-analysis to find studies that used BMSC-seeded implants in animal models of focal knee cartilage defects. The histological evaluation of integration quality’s quantitative results was extracted. The morphology and staining characteristics of the repaired cartilage were also recorded. In comparison to cell-free comparators and control groups, high-quality integration was achieved, as shown by meta-analysis. Repair tissue morphology and staining properties that were comparable to those of natural cartilage were associated with this. Studies that made use of poly-glycolic acid-based scaffolds had better integration outcomes, according to subgroup analysis. In conclusion, BMSC-seeded implants are promising options for improving the repair of focal cartilage defects. High-quality integration scores suggest that these implants could generate repair cartilage of significant longevity, despite the fact that a greater number of studies involving human patients are required to realize the full clinical potential of BMSC therapy