Valve thrombosis is an important problem of surgical valves and also newer generation transcatheter valves. Valve thrombosis has been reported in different transcatheter valves, such as Edwards and Corevalve valves. Valve thrombosis after Lotus valve implantation has not been reported. To the best of our knowledge, this is the first report in the literature of a Lotus valve thrombosis. The patient discharged home on aspirin and clopidogrel after procedure, however she became symptomatic soon and the diagnosis of prosthetic valve malfunction due to thrombosis was made. Patient treated with anticoagulant therapy.