ISSN: 2041-6792

Clinical Investigation

Phosphotransferase Top Open Access Journals

 Phosphotransferases are a category of enzymes and their EC number 2.7 which that catalyze phosphorylation reactions. The general form of the reactions they catalyze is: A-P + B {\displaystyle \rightleftharpoons }\rightleftharpoons  B-P + A, Where P is a phosphate group and A and B are the donating and accepting molecules, respectively. Phosphotransferases are generally classified according to the acceptor molecule: EC 2.7.1, EC 2.7.2, EC 2.7.3, EC 2.7.4, EC 2.7.9 Phosphotransferases with an alcohol group as acceptor, carboxy group as acceptor, nitrogenous group as acceptor, phosphate group as acceptor, Phosphotransferases with paired acceptors. A single triphosphate-nucleotide transfers two phosphates to two different acceptor molecules, resulting in a monophosphate-nucleotide and two phosphorylated products in these reactions. The phosphotransferase system (PTS) is a complex group translocation system present in many bacteria. The PTS transports different forms of sugars such as glucose, mannose, and mannitol into the cell. The phosphorylation of the substrate via phosphotransferase during transport is first step of this reaction. This Glc-6P can no longer freely leave the cell Due to the negative charge of the phosphate. This is the first reaction of glycolysis, which degrades the sugar to pyruvate.    

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