ISSN: 2048-9145

Pharmaceutical Bioprocessing

Microscopic Colitis Innovations

 Microscopic colitis can be characterized as a clinical syndrome of unknown etiology, consisting of chronic, watery diarrhea, with no or limited colonoscopic changes seen. So only histology can make a definitive diagnosis. Over the past few years, the epidemiological characteristics of this disease have become more elaborate, with most data coming from Western countries. Microscopic colitis includes two histological subtypes [collagenous colitis (CC) and lymphocytic colitis (LC)] with no differences in clinical presentation and management. Collagenous colitis is characterized by a thickening of the sub epithelial collagen layer which is not seen in LC. The main feature of LC is an increase in the density of intra-epithelial lymphocytes in the surface epithelium.  

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