HIV Co-infection Top Open Access Journals
Despite the increasing availability of combination
antiretroviral therapy (cART), nearly 1.5 million deaths were attributed to human
immunodeficiency virus (HIV) in 2010 (1). The
immunodeficiency caused by chronic HIV
infection increases the danger of co-infection with pathogens that are controlled by innate and adaptive cellular immune responses and a few that are controlled by phagocytic antibody responses. Furthermore,
administration of cART within the setting of HIV co-infection doesn't always restore the pathogen-specific immune reaction to normal levels. Here we review the immune
pathogenesis of the five leading infectious diseases that still cause significant
morbidity and mortality in HIV-infected individuals globally:
tuberculosis (TB), cryptococcosis,
hepatitis B virus (HBV),
hepatitis C virus (HCV), and malaria. Understanding the complex interaction between HIV, these co-infections, and therefore the host immune reaction is central to developing new strategies for optimal treatment and prevention. Further, we discuss the beneficial impact and potential risks of cART on the explanation of those co-infections, with a specific specialise in immune restoration disease
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